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Meloxicam Interaction With Alcohol- It’s well known that taking alcohol and painkillers together is a terrible idea, but how dangerous would it be to drink alcohol while taking arthritis medication like Meloxicam? The short answer: It’s very risky. It’s powerful and can cause major heart and gastrointestinal problems that could be life-threatening. Additionally, many of the specific side effects of this medication overlap with those caused by alcohol use. Read on to learn more about the side effects of mixing meloxicam and alcohol, Visit our online website.