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Lithium And Alcohol - Lithium and alcohol are both substances that act on the central nervous system. When taken together, they not only increase the concentration of lithium in the blood and increase the risk of an overdose, but they also cancel out the mood-stabilizing effects of lithium. Other consequences of mixing alcohol and lithium include thyroid issues and a sodium imbalance. For these reasons, it is not safe to consume lithium and alcohol at the same time and patients who are prescribed this mood stabilizer are advised to avoid alcohol consumption. Someone who struggles with alcohol addiction and a mental health disorder may have a more difficult time overcoming substance abuse if they do not have their mental health in check. However, finding a medication regime to manage mental health without causing dangerous effects from alcohol consumption can be tricky.